Platelet Aggregation in Waldenstrom’s Macroglöbulinaemia*

Summary

The morphology of coagula obtained in the cone in cone viscometer is studied in two cases of Waldenstrom’s macroglobulinaemia. Whereas the structures obtained in normal individuals have the features of in vivo thrombosis, the platelet masses usually obtained are not present in the two patients studied. It is postulated that disturbance of platelet aggregation as demonstrated may account for the bleeding diathesis in some cases of Waldenstrom’s macroglobulinaemia.

• References

• 1 Waldenstrom J. Incipient myelomatosis or essential hyperglobulinaemia with fibrinogenopenia-anew syndrome ? Acta. med. scand. 117: 216 1944;
• 2 Pachter M. R, Johnson S. A, Neblett T. R, Truant J. P. Bleeding, platelets and macroglobulinaemia. Amer. J. clin. Path. 31: 467 1959;
• 3 Izarn P. Les anomalies dn temps de saignement an cours des dysglobulinemies. Nonv. Rev. franc. Hémat. 03: 340 1963;
• 4 Perry S. Coagulation factors in patients with plasma protein disorders. J. Lab. clin. Med. 61: 411 1963;
• 5 Rozenberg M. C, Dintenfass L. Thrombus formation in vitro: a rheological and morphological study. Aust. J. exp. Biol. med. Sci. 42: 109 1964;
• 6 Dintenfass L, Rozenberg M. C. The effect of velocity gradient on the coagulation of blood. J. Atheroscler. Res. (In press.)
• 7 Dintenfass L. Thixotropy of blood and proneness to thrombus formation. Circulât. Res. 11: 233 1962;
• 8 Dintenfass L. Viscosity and clotting of blood in venous thrombosis and coronary occlusion. Circulât. Res. 14: 1 1964;
• 9 Proctor R. B, Rapjpaport S. I. The partial thromboplastin time with kaolin. Amer. J. clin. Path. 36: 212 1961;
• 10 Biggs R, MacFarlane R. G. Human blood coagulation. 3rd. ed. Blackwell scientific publications; 1962
• 11 Butler E. A, Flynn F. V, Hanis H, Robson E. B. The laboratory diagnosis of macroglobulinaemia. Lancet II: 289 1961;
• 12 Roskam J. Erreurs anciennes et perspectives neuvelles dans l’etude de l’adhesion, de l’aggregation, et de la metamorphose visqueuse des plaquettes, facteurs d’hemostase. Thromb. Diathes. haemorrh. (Stuttg) 10: 253 1963;
• 13 Bizzozero J. Über einen neuen Formbestandteil des Blutes und dessen Rolle bei der Thrombose und der Blutgerinnung. Virchows Arch. path. Anat. 90: 261 1882;
• 14 Braunsteiner H, Falkner R, Neumayer A, Pakesch F. Makromoleculare Kryoglobulinaemie. Klin. Wschr. 32: 722 1954;
• 15 Borchgrevink ChF. Platelet adhesion in vivo in patients with bleeding disorders. Acta, med. scand. 170: 245 1965;
• 16 Jorgensen L, Borchgrevink ChF. The haemostatic mechanism in patients with haemorrhagic diseases. A histological study of wounds made for primary and secondary bleeding time tests. Acta. path, microbiol. scand. 60: 55 1964;